Search - CaspSites

Enter your list of proteins - max 250 substrates: (leave blank to search all substrates)

Enter each protein on a new line; search will work best with accession number or UniProt ID
- please choose from the human proteome (CaspSites only stores human caspase substrates)

Cleavage Site Information:

Protease subsite nomenclature is reported as the P4-P4' site (Schechter & Berger, 1967). The four amino acids prior to cleavage of the peptide bond (N-terminal) are designated as the P4, P3, P2, and P1 residues. Similarly, the four residues after the cleaved bond (C-terminal) are designated as P1', P2', P3' and P4'.

- Caspases preferentially cleave substrates after aspartic acid residues (P1 = D)

Select a Cleavage Site:

P1 = D (all caspase targets)

Custom Site (select P4-P4' residues below):

P4 Residue:

P3 Residue:

P2 Residue:

P1 Residue:

P1' Residue:

P2' Residue:

P3' Residue:

P4' Residue:

Enter list of P4-P1 sequences - use "X" for any amino acid:

For best functionality, separate P4-P1 sequences using a comma or space.
- sequences must each be exactly four characters long.

Created by Henry Wang @ Julien Lab, Department of Biochemistry

Enter your list of proteins - max 250 substrates: (leave blank to search all substrates)

Select a dataset: (double-click select all to remove all)

Exclude the following datasets from searches: (hold control to select multiple)

Cleavage Site Information:

Select a Cleavage Site: